In this study, we aim to assess the effect of Kyolic aged garlic extract on:

• Arterial stiffness, assessed by measuring how fast your blood travels through your blood vessels (pulse wave analysis)
• Aerobic fitness, assessed by high intensity exercise VO2max test on a cycle ergometer
• Lactate threshold, assessed by lactate levels during VO2max testing
• Muscular soreness and recovery, assessed by questionnaire
• Cardiovascular proteomic biomarkers, assessed by urine spot test (subgroup)
• Microcirculation, assessed by video microcapillary microscopy

Update Oct 2023: Recruitment for the trial is now closed.

• Participants:
• 40-65 year old active adults with elevated arterial stiffness*
• Who regularly undertake a minimum of 3x30min/week moderate to high intensity exercise (e.g. triathlon, cycling, running, swimming) *Measuring arterial stiffness
• *To assess eligibility, you will need to attend a 30 min screening visit at NIIM, where we will test your arterial stiffness with a hand-held gold-standard blood pressure tonometer.

Eligible participants will

• Attend 4 appointments at NIIM over a 3 months period, at baseline, 4 weeks, 8 weeks, and 12 weeks.
• Attend 2 appointments at METS Performance Consulting in Mulgrave, VIC at baseline and after 12 weeks, to undertake the VO2max testing on a cycle ergometer. Please allow at least 1 hour for testing.
• Take 2-4 trial capsules a day for 3 months.

In this randomised placebo-controlled double-blind dose-response trial, half of the participants will be randomly allocated to the active capsules which contain the odourless aged garlic extract (Kyolic®), and half of the participants will receive placebo capsules.

The study will be conducted at NIIM, 21 Burwood Road, Hawthorn VIC 3122.

Please note – Participants need to be located in Victoria, and need to be able to come to the NIIM clinic in Melbourne.

Update Oct 2023: Recruitment for the trial is now closed. Thank you for your interest.

Any questions? Contact: [email protected]